Application
Western blot analysis of OSX expression in human fetal kidney tissue extract.Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human intestine tissue showing nuclear localization.| Product Name | OSX Antibody (Y-21) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of OSX of human origin by WB, IP, IF, IHC(P) and ELISA |
| Conjugation | Agarose |
| Modification | Acetylated |
| Modification Notes | Osterix (OSX) is a zinc finger-containing transcriptional activator that is distinctly expressed in all developing bones and is important for osteoblast differentiation. In particular, OSX is implicated in the differentiation of osteo-blasts, which are the specialized cells of bone formation. OSX is a nuclear protein that binds to GC box promoters elements and activates mRNA synthesis from genes containing functional recognition sites. The periosteal and mesenchymal cells of the membranous skeletal elements of OSX- mice fail to differentiate into osteoblasts. Subsequently, the mesenchymal cells of OSX- mice fail to deposit bone matrix and do not form bone. Cox-2 deficiency correlates with a decrease in OSX expression, suggesting that Cox-2 may induce OSX to mediate skeletal repair. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHCIPWB |
| WB:1:100~1:400 IP:1:20~1:100 IF:1:20~1:100 IHC:1:10~1:50 |
|
| Species Reactivity | HumanMouseRatRhesus Monkey |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of OSX of human origin by WB IP IF IHC(P) and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of OSX of human origin by WB, IP, IF, IHC(P) and ELISA |
| Entrez Gene | 121340 |
|---|
Application
Western blot analysis of OSX expression in human fetal kidney tissue extract.
Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human intestine tissue showing nuclear localization.| Application Notes | WB:1:100~1:400 IP:1:20~1:100 IF:1:20~1:100 IHC:1:10~1:50 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
