| Product Name | ERBIN Antibody (H-210) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 861-1070 mapping within an internal region of ERBIN of human origin |
| Modification Notes | The ErbB-2 receptor tyrosine kinase evolved as a shared coreceptor of all ErbB-specific growth factors and acts as a coordinator of a variety of biological signaling networks (1,2). ErbB-2 couples ErbB receptors to the migration/invasion machinery of carcinoma cells by employing adaptor proteins, such as p130CAS and c-CrkII, which regulate the actin-myosin cytoskeleton of migratory cells (2,3). ErbB-2 is expressed in basal cells of sqamous epithelia and is important in the morphogenesis and oncogenesis of secretory epithelia (4,5). In epithelia, ErbB-2 employs the adaptor protein ERBIN (ErbB-2 interacting protein), which functions in the localization and signaling of ErbB-2 (4). ERBIN contains a PDZ domain that directly and specifically interacts with ErbB-2, causing ERBIN and ErbB-2 to colocalize to the lateral membrane of intestinal epithelial cells (4). ERBIN provides further evidence to support the claim that the tumorigenic action of ErbB-2 may be attributed to its ability to acts as a shared signaling subunit, rather than functioning as a distinct receptor (5). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ERBIN of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 861-1070 mapping within an internal region of ERBIN of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 861-1070 mapping within an internal region of ERBIN of human origin |
| Entrez Gene | 55914 |
|---|
| Application Notes | recommended for detection of ERBIN of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
