Application
Western blot analysis of STRAP expression in rat brain tissue extract.| Product Name | STRAP Antibody (H-116) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-116 mapping at the N-terminus of STRAP of human origin |
| Modification Notes | Smad proteins play an important role in the intracellular signalling of the TGF∫ superfamily of extracellular polypeptides. Two Smad proteins, Smad6 and Smad7, function as antagonists to TGF∫ signalling. STRAP, another antagonist to the TGF∫ signalling pathway, specifically interacts with Smad7, but not Smad6, to synergistically block TGF∫-induced transcriptional activation. The gene encoding the human homolog of STRAP (as designated in mouse), called unr-interacting protein, maps to chromosome 12p12.3. Unr-interacting protein is 97% homologous to STRAP at the amino acid level. The unr-interacting protein binds unr, a cytoplasmic RNA-binding protein with five cold-shock domains that is involved in RNA translation. The presence of the STRAP gene in a variety of species from mammals to yeast, indicates that STRAP function is evolutionarily conserved in eukaryotic cells. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of STRAP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-116 mapping at the N-terminus of STRAP of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-116 mapping at the N-terminus of STRAP of human origin |
| Entrez Gene | 11171 |
|---|
Application
Western blot analysis of STRAP expression in rat brain tissue extract.| Application Notes | recommended for detection of STRAP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
