Application
Western blot analysis of TPMT expression in human bone marrow tissue extract.| Product Name | TPMT Antibody (H-78) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 38-115 mapping within an internal region of TPMT of human origin |
| Modification Notes | Thiopurine S-methyltransferase (TPMT), also designated thiopurine methyltransferase, acts as a catalyst for the S-methylation of thiopurine drugs such as 6-mercaptopurine. TPMT, usually found as a monomer, is inhibited by S-adenosyl-L-homocysteine. It is a cytoplasmic protein belongs to the TPMT subfamily of the larger methyltransferase superfamily of proteins. TPMT activity varies among different ethnic groups, with a large majority of Caucasians having a high TPMT activity. A common genetic polymorphism controls the level of TPMT activity. The level of TPMT activity is associated with the variation in efficacy and toxicity of thiopurine drugs. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TPMT of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 38-115 mapping within an internal region of TPMT of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 38-115 mapping within an internal region of TPMT of human origin |
| Entrez Gene | 7172 |
|---|
Application
Western blot analysis of TPMT expression in human bone marrow tissue extract.| Application Notes | recommended for detection of TPMT of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
