| Product Name | R-Spondin2 Antibody (H-55) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 163-217 mapping near the C-terminus of R-Spondin2 of human origin |
| Modification Notes | Roof plate-specific Spondins (R-Spondins) are secreted proteins that possess a Furin-like cysteine-rich domain and are involved in regulating ∫-catenin function. R-Spondin2, also known as RSPO2 or CRISTIN2, is a 243 amino acid secreted protein that contains one FU repeat and one TSP type-1 domain. Existing as multiple alternatively spliced isoforms, R-Spondin2 interacts with Wnt-1 and functions to activate the ∫-catenin signaling cascade, ultimately leading to TCF-dependent gene activation. Additionally, R-Spondin2 is thought to act as a ligand for LRP and frizzled receptors. The gene encoding R-Spondin2 maps to human chromosome 8, which encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that maps to chromosome 8. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of R-Spondin2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 163-217 mapping near the C-terminus of R-Spondin2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 163-217 mapping near the C-terminus of R-Spondin2 of human origin |
| Entrez Gene | 340419 |
|---|
| Application Notes | recommended for detection of R-Spondin2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
