| Product Name | Cdc20B Antibody (E-12) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of Cdc20B of human origin |
| Modification Notes | WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. Cdc20B (cell division cycle 20 homolog B) is a 519 amino acid protein that contains seven WD repeats and is thought to play a role in cell cycle control. Multiple isoforms of Cdc20B exist due to alternative splicing events. The gene encoding Cdc20B maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of Cdc20B isoforms 1-5 of mouse and human origin by WB, IF and ELISA non cross-reactive with Cdc20 also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of Cdc20B of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of Cdc20B of human origin |
| Entrez Gene | 166979 |
|---|
| Application Notes | recommended for detection of Cdc20B isoforms 1-5 of mouse and human origin by WB, IF and ELISA non cross-reactive with Cdc20 also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
