Application
Western blot analysis of TRIP6 expression in non-transfected: (A) and human TRIP6 transfected: (B) 293T whole cell lysates.| Product Name | TRIP6 Antibody (M-87) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 8-94 mapping near the N-terminus of TRIP6 of mouse origin |
| Modification Notes | Zyxin is a LIM domain-containing, zinc finger domain-containing, SH3 ligand-containing phosphoprotein that localizes to focal adhesion plaques and actin filament bundles. Thyroid receptor interacting protein 6 (TRIP6) is a Zyxin-related protein. TRIP6 interacts with the ligand binding domain of the thyroid receptor and is predominantly expressed in kidney, liver and lung. It interacts with receptor-interacting protein 2 (RIP2) through LIM domains in a TNF- or IL-1-dependent manner. TRIP6 also interacts with TRAF2, a protein that is crucially involved in TNF signaling, as well as the IL-1 receptor, TLR2 and Nod1. Overexpression of TRIP6 facilitates NFkappaB activation by TNF, IL-1, TLR2 or Nod1, whereas a dominant negative mutant or RNA-interference construct of TRIP6 inhibits NFkappaB activation by TNF, IL-1, TLR2 or Nod1. Moreover, TRIP6 also potentiates RIP2- and Nod1-mediated ERK activation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TRIP6 of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 8-94 mapping near the N-terminus of TRIP6 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 8-94 mapping near the N-terminus of TRIP6 of mouse origin |
| Entrez Gene | 7205 |
|---|
Application
Western blot analysis of TRIP6 expression in non-transfected: (A) and human TRIP6 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of TRIP6 of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
