Application
Western blot analysis of BLCAP expression in non-transfected: (A) and human BLCAP transfected: (B) 293T whole cell lysates.| Product Name | BLCAP Antibody (C-12) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the C-terminus of BLCAP of human origin |
| Modification Notes | BLCAP (Bladder cancer-associated protein) is an 87 amino acid highly conserved multi-pass transmembrane protein that is highly expressed in normal esophagus, thyroid and brain tissue. Overexpression of BLCAP inhibits cell growth and initiates apoptosis via upregulation of p21 and downregulation of Bcl-xL and Bcl-2. Since p53 and NF˚B activity remain unchanged, the regulation of the cell cycle and apoptosis by BLCAP represents a novel pathway independent of p53 and NF˚B. Transcription of the gene encoding BLCAP is almost completely repressed in high invasive transitional cell carcinomas. Additionally, BLCAP is expressed in all non-cancerous cervical tissues, but expression is lost in primary cervical cancer tissue. This evidence suggests that BLCAP may be a suitable marker for carcinogenic invasiveness and progression. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of BLCAP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and feline: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the C-terminus of BLCAP of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the C-terminus of BLCAP of human origin |
| Entrez Gene | 10904 |
|---|
Application
Western blot analysis of BLCAP expression in non-transfected: (A) and human BLCAP transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of BLCAP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and feline: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
