epitope mapping at the C-terminus of ZNF271 of human origin
Modification Notes
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF271 (Zinc finger protein 271), also known as Zinc finger protein 7, HZF7 and Epstein-Barr virus-induced zinc finger protein, is a 655 amino acid nuclear protein that contains 19 C2H2-type zinc fingers. ZNF271 is expressed in pancreatic islet cells, T-cell lines, thryoid and thymocytes. Interestingly, ZNF271 plays a significant role in Epstein-Barr virus transformation. The gene encoding ZNF271 maps to a chromosomal region that is frequently associated with hematopoietic malignancies. There are two isoforms of ZNF271 that are produced as a result of alternative splicing events.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of ZNF271 of human origin by WB, IP, IF and ELISA also reactive with additional species, including porcine:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope mapping at the C-terminus of ZNF271 of human origin
Tissue Specificity
epitope mapping at the C-terminus of ZNF271 of human origin