Application
Western blot analysis of human recombinant CV-2.| Product Name | Crossveinless-2 Antibody (H-189) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 497-685 mapping at the C-terminus of Crossveinless-2 of human origin |
| Modification Notes | Crossveinless-2, also known as BMP-binding endothelial regulator protein, Cvl2 or Cv2, is a member of the Chordin family. It is an evolutionarily conserved protein that was first identifed in Drosophila where it is required for the formation of cross-veins in the wing. Crossveinless-2 is a developmentally secreted glycoprotein that contains a trypsin inhibitory-like (TIL) domain, five von Willebrand factor type C (VWFC) domains and one VWF type D (VWFD) domain. Crossveinless-2 regulates BMP homeostasis in early vertebrate embryonic tissues via its cysteine-rich BMP-binding domains. It is expressed during development at sites of high BMP signaling and its expression is responsive to this signaling thereby providing positive feedback. Crossveinless-2 directly interacts with BMP4 and BMP2 and can function either to enhance or inhibit BMP signaling. Crossveinless-2 may function to promote BMP signaling by aiding in ligand transport. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Crossveinless-2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 497-685 mapping at the C-terminus of Crossveinless-2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 497-685 mapping at the C-terminus of Crossveinless-2 of human origin |
| Entrez Gene | 168667 |
|---|
Application
Western blot analysis of human recombinant CV-2.| Application Notes | recommended for detection of Crossveinless-2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
