| Product Name | ELKS Antibody (H-48) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 112-159 mapping near the N-terminus of ELKS of human origin |
| Modification Notes | The glutamine, leucine, lysine, and serine-rich protein ELKS, also designated Rab6-interacting protein 2 and CAZ-associated structural protein (CAST) or the acronym ERC, is a member of a family of RIM-binding proteins. RIMs are presynaptic active zone proteins that regulate neurotransmitter release. This class of protein functions by recruiting I˚Bå to the I˚B kinase (IKK) complex, and thus serves a regulatory function for IKK activation. Five isoforms of ELKS (Alpha, Beta, Gamma, Delta, and Epsilon) exist and have multiple coding region differences and distinct C-termini. Only brain-specific ELKS bind to RIMs, but both ubiquitous and brain-specific ELKS bind to Rab6, a GTP-binding protein involved in membrane traffic at the Golgi complex. Fusion of ELKS to RET due to translocation t(10;12)(q11;p13) results in a papillary thyroid carcinoma. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ELKS of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 112-159 mapping near the N-terminus of ELKS of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 112-159 mapping near the N-terminus of ELKS of human origin |
| Entrez Gene | 23085 |
|---|
| Application Notes | recommended for detection of ELKS of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
