Application
Western blot analysis of COQ7 expression in mouse liver (A), mouse heart (B), mouse kidney (C) and rat skeletal muscle (D) tissue extracts.| Product Name | COQ7 Antibody (FL-217) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-217 representing full length COQ7 of human origin |
| Modification Notes | COQ7, a Timing protein CLK-1 homolog, is a 217 amino acid protein encoded by the mouse gene Coq7. It is believed that COQ7/CLK-1 is required for the biosynthesis of Coenzyme Q (COQ), an essential co-factor in mitochondrial respiration. In yeast, mutation of the COQ7 gene results in the absence of UQ biosynthesis and demonstrates a role for this gene in the step leading to the hydroxylation of 5-demethoxyubiquinone. COQ7 may also be responsible for maintenance of mitochondrial integrity and neurogenesis. COQ7 is highly expressed in tissues with high energy demand such as heart, muscle, liver, and kidney. After transcription, COQ7 is targeted to the mitochondria where it is processed to its mature form. The protein similarities and the conservation of function of the CLK-1/clk-1/COQ7 gene products suggest a potential link between the production of ubiquinone and aging. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of COQ7 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-217 representing full length COQ7 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-217 representing full length COQ7 of human origin |
| Entrez Gene | 10229 |
|---|
Application
Western blot analysis of COQ7 expression in mouse liver (A), mouse heart (B), mouse kidney (C) and rat skeletal muscle (D) tissue extracts.| Application Notes | recommended for detection of COQ7 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
