Application
Western blot analysis of TMPRSS4 expression in MIA PaCa-2 whole cell lysate.| Product Name | TMPRSS4 Antibody (H-76) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. TMPRSS4 (transmembrane protease, serine 4), also known as MT-SP2 (membrane-type serine protease 2) and initially referred to as TMPRSS3, is a single-pass type II membrane protein with one SRCR domain, one LDL-receptor class A domain and one peptidase S1 domain. Localizing to the cell surface, TMPRSS4 is a member of the peptidase S1 family and is weakly expressed in normal tissues but is highly expressed in gastric, pancreatic, ampullary and colorectal cancer. TMPRSS4 plays a role in metastasis formation and tumor invasion. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TMPRSS4 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 295-370 mapping within an internal region of TMPRSS4 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 295-370 mapping within an internal region of TMPRSS4 of human origin |
| Entrez Gene | 214523 |
|---|
Application
Western blot analysis of TMPRSS4 expression in MIA PaCa-2 whole cell lysate.| Application Notes | recommended for detection of TMPRSS4 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
