| Product Name | H-ficolin Antibody (H-55) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 166-220 mapping within an internal region of H-ficolin of human origin |
| Modification Notes | H-ficolin (Ficolin-3, Collagen/fibrinogen domain-containing lectin 3 p35, Hakata antigen) is a 299 amino acid protein encoded by the human gene FCN3. H-ficolin belongs to the ficolin lectin family and contains one collagen-like domain and one fibrinogen C-terminal domain. Ficolins and mannose-binding lectin (MBL) are collagen-like defence proteins that serve as recognition molecules in lectin complement pathway. H-ficolin is a collagen-like defense molecule and is a known autoantigen in patients with systemic lupus erythematosus (SLE). Other collagen-like defense molecules, such as C1q, mannose-binding lectin (MBL) and L-ficolin, bind to apoptotic cells and mediate their clearance by phagocytic cells. Dysfunction in this mechanism is regarded as an important contributor to the pathophysiology of SLE. H-ficolin mediates the clearance of late apoptotic cells and is involved in the maintenance of tissue homeostasis and might play a protective role against the development of autoimmunity. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of H-ficolin of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 166-220 mapping within an internal region of H-ficolin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 166-220 mapping within an internal region of H-ficolin of human origin |
| Entrez Gene | 8547 |
|---|
| Application Notes | recommended for detection of H-ficolin of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
