| Product Name | WHIP Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 366-665 mapping at the C-terminus of WHIP of human origin |
| Modification Notes | Werner’s syndrome is an inherited, autosomal recessive disorder that is characterized by premature aging and commonly results in cancer. WHIP, also known as WRNIP1 (Werner helicase-interacting protein 1) is a ubiquitously expressed member of the AAA ATPase family that is involved in the regulation of DNA synthesis. Localized to the nucleus, WHIP acts as a modulator for initiation events during DNA polymerase-mediated DNA synthesis and, through its ATPase activity, can detect DNA damage or arrested replication forks. WHIP is found in granular structures within the nucleus, where it interacts with the N-terminal domain of WRN, the protein product of the gene responsible for Werner’s syndrome. Due to its close association with WRN, WHIP is thought to be involved in the aging process and thus may play a role in the development of Werner’s syndrome. Four isoforms of WHIP are produced due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of WHIP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 366-665 mapping at the C-terminus of WHIP of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 366-665 mapping at the C-terminus of WHIP of human origin |
| Entrez Gene | 56897 |
|---|
| Application Notes | recommended for detection of WHIP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
