| Modification Notes |
BTBD1 (BTB/POZ domain containing 1), also known as NS5ATP8 (hepatitis C virus (HCV) NS5A-transactivated protein 8), is a ubiquitously expressed cytoplasmic protein with predominant expression in skeletal muscle and heart. BTBD1 is expressed in a wide variety of species ranging from C. elegans to humans and specifically localizes to cytoplasmic bodies. It shares 80% amino acid sequence identity with its homolog, BTBD2. BTBD1 contains one BTB/POZ domain, which is a hydrophobic-rich motif known to mediate homomeric and heteromeric POZ-POZ interactions that are commonly found at the N-terminus of developmentally regulated zinc-finger transcription factors. BTBD1 also contains a C-terminal kelch-like region and a PHR-like region. Via its C-terminus, BTBD1 is capable of interacting with Topo I. In addition, BTBD1 is required for myoblast growth and differentiation. |