Application
Western blot analysis of SMC6 expression in non-transfected: (A) and human SMC6 transfected: (B) 293T whole cell lysates.| Product Name | SMC6 Antibody (H-228) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 845-1072 mapping near the C-terminus of SMC6 of human origin |
| Modification Notes | Breaks in double stranded DNA often arise during DNA replication or as a result of exposure to DNA-damaging agents. Quick and accurate repair of these breaks is crucial for cell survival and genomic stability. Structural maintenance of chromosomes (SMC) family members form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation during mitosis. Two distinct SMC protein complexes are the SMC1/SMC3 heterodimer and the SMC2/SMC4 heterodimer. SMC5 and SMC6 play a crucial role in DNA repair as they form a complex that, along with SUMO ligase, is also important in preventing DNA damage-induced apoptosis. This complex made up of SMC5 and SMC6 is crucial for sister chromatid homologous recombination DNA repair and also for prevention of chromosomal rearrangements. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SMC6 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 845-1072 mapping near the C-terminus of SMC6 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 845-1072 mapping near the C-terminus of SMC6 of human origin |
Application
Western blot analysis of SMC6 expression in non-transfected: (A) and human SMC6 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of SMC6 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
