Application
Western blot analysis of TMEM46 expression in Hs 67 whole cell lysate.| Product Name | TMEM46 Antibody (K-20) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within a cytoplasmic domain of TMEM46 of human origin |
| Modification Notes | TMEM46 (transmembrane protein 46), also known as shisa-2 homolog, is a 295 amino acid protein encoded by a gene mapping to human chromosome 13. Comprising nearly 4% of human DNA, chromosome 13 contains around 114 million base pairs and 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. RB1 encodes a crucial tumor suppressor protein which, when defective, leads to malignant growth in the retina and has been implicated in a variety of other cancers. The gene SLITRK1, which is associated with Tourette syndrome, is on chromosome 13. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TMEM46 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other TMEM family members also reactive with additional species, including equine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within a cytoplasmic domain of TMEM46 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within a cytoplasmic domain of TMEM46 of human origin |
| Entrez Gene | 387914 |
|---|
Application
Western blot analysis of TMEM46 expression in Hs 67 whole cell lysate.| Application Notes | recommended for detection of TMEM46 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other TMEM family members also reactive with additional species, including equine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
