Application
Western blot analysis of Pan3 expression in mouse thymus tissue extract.Application
Western blot analysis of Pan3 expression in NIH/3T3 whole cell lysate.| Product Name | Pan3 Antibody (D-19) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the C-terminus of Pan3 of human origin |
| Modification Notes | Pan3 (PAB-dependent poly(A)-specific ribonuclease subunit 3) is a 741 amino acid cytoplasmic protein belonging to the protein kinase superfamily. Containing a protein kinase domain, Pan3 is a component of the Pan nuclease complex and recruits polyadenylate-binding protein, which in turn stimulates Pan2 nuclease activity. It is suggested that Pan3 may have a functional role in cytoplasmic mRNA decay. Pan3 exists as three isoforms produced by alternative splicing and the gene encoding Pan3 is located on human chromosome 13. Chromosome 13 houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Pan3 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with isoforms Pan3b, 2 and 3 also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the C-terminus of Pan3 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the C-terminus of Pan3 of human origin |
| Entrez Gene | 255967 |
|---|
Application
Western blot analysis of Pan3 expression in mouse thymus tissue extract.
Application
Western blot analysis of Pan3 expression in NIH/3T3 whole cell lysate.| Application Notes | recommended for detection of Pan3 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with isoforms Pan3b, 2 and 3 also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
