Application
Western blot analysis of PDE6D expression in non-transfected: (A) and mouse PDE6D transfected: (B) 293T whole cell lysates.| Product Name | PDE6D Antibody (FL-150) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-150 representing full length PDE6D of human origin |
| Modification Notes | Phosphodiesterases (PDEs), also designated cyclic nucleotide phosphodiesterases, are important for the downregulation of the intracellular level of the second messenger cyclic adenosine monophosphate (cAMP) by hydrolyzing cAMP to 5'AMP. The PDE family contains proteins that serve tissue-specific roles in the regulation of lipolysis, glycogenolysis, myocardial contractility and smooth muscle relaxation. PDE6D, also designated phosphodiesterase 6D cGMP-specific rod ∂, is a retina-specific oligomer composed of two catalytic chains (å and ∫), an inhibitory chain (©) and the ∂ chain. It interacts with RPGR, ARL2 and ARL3, and contains 150 amino acids, which are unusually well conserved, with only a few conservative substitutions in human, cow, mouse and rat PDE6D. The PDE6D protein contains two N-linked glycosylation sites. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PDE6D of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-150 representing full length PDE6D of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-150 representing full length PDE6D of human origin |
Application
Western blot analysis of PDE6D expression in non-transfected: (A) and mouse PDE6D transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of PDE6D of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
