| Product Name | CLEC-1 Antibody (H-101) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 124-224 mapping within an internal region of CLEC-1 of human origin |
| Modification Notes | The human b-glucan protein (Dectin-1) is a small, type II transmembrane receptor that enables b-glucan-dependent, nonopsonic recognition of zymosan and other yeast-derived particles by primary macrophages. Dectin-1 is the human homolog of the C-type (calcium dependent) lectin-like receptor (CLEC) family that play an important role in regulating innate immunity. CLEC-1 is a 280 amino acid single-pass type II transmembrane protein expressed in dendritic and endothelial cells. It accumulates in perinuclear compartments and requires an associated chain to reach the cell surface. CLEC-1 is involved in antigen uptake and is homologous to the natural killer (NK) cell receptors, NKG2s and CD94, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. It has a single carbohydrate recognition domain with six conserved and two additional cysteine residues. Additionally, CLEC-1 has a cytoplasmic immuno-receptor tyrosine-based motif and many potential phosphorylation sites. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CLEC-1 of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 124-224 mapping within an internal region of CLEC-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 124-224 mapping within an internal region of CLEC-1 of human origin |
| Entrez Gene | 51267 |
|---|
| Application Notes | recommended for detection of CLEC-1 of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
