Application
Western blot analysis of MTBP expression in K-562 whole cell lysate.| Product Name | MTBP Antibody (H-40) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 654-693 mapping within an internal region of MTBP of human origin |
| Modification Notes | p53 is a critical coordinator of a wide range of stress responses. To facilitate a rapid response to stress, p53 is produced constitutively, but is negatively regulated by MDM2. MTBP (also designated MDM2BP or MDM2 transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein) is a growth regulator that modulates the activity of MDM2 towards itself and p53, and thereby contributes to MDM2-dependent p53 homeostasis in cells. Specifically, MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization. MTBP transcript is most abundant in thymus, testis and ovary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MTBP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 654-693 mapping within an internal region of MTBP of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 654-693 mapping within an internal region of MTBP of human origin |
| Entrez Gene | 27085 |
|---|
Application
Western blot analysis of MTBP expression in K-562 whole cell lysate.| Application Notes | recommended for detection of MTBP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
