| Product Name | AKAP 82 Antibody (H-50) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 781-830 mapping near the C-terminus of AKAP 82 of human origin |
| Modification Notes | AKAP (A-kinase anchoring proteins) is a family of proteins that interact with the R subunit of PKA to anchor it to specific sites within the cell in order to maintain the specificity of PKA signalling. Members of this family display differential tissue specificity and localization. AKAP 82, also known as PRKA4 (protein kinase A-anchoring protein 4), major sperm fibrous sheath protein or FSC1, is expressed in spermatid during spermiogenesis. AKAP 82 plays an important role in spermatid development, completing the fibrous sheath assembly. AKAP 82 has two binding sites for PKA, one specific for RIå and one that can bind either RIå or RIIå. AKAP 82 also binds to AKAP 3. These two proteins together make up most of the insoluble fibrous sheath. In AKAP 82 knockout spermatozoa, a significant reduction or loss of AKAP 3, RIIå, SP17 and GAPDS results. Abnormal sperm expression of AKAP 82 may be involved in asthenospermia. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of AKAP 82 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 781-830 mapping near the C-terminus of AKAP 82 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 781-830 mapping near the C-terminus of AKAP 82 of human origin |
| Entrez Gene | 8852 |
|---|
| Application Notes | recommended for detection of AKAP 82 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
