| Product Name | VPRBP Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1101-1400 mapping near the C-terminus of VPRBP of human origin |
| Modification Notes | Infection by human immunodeficiency virus (HIV) is associated with an early immune dysfunction and progressive destruction of CD4+T lymphocytes. The HIV-induced, premature destruction of lymphocytes is associated with the continuous production of HIV viral proteins, which modulate apoptotic pathways. The virion-associated protein (Vpr), an accessory protein of HIV, affects viral replication, as well as cell growth, differentiation and apoptosis. Involved in the pathogenesis of T cell depletion in HIV-infected people, Vpr has been shown to enhance the nuclear transport of the HIV-1 pre-integration complex, activate transcription of cellular and viral promoters and arrest the cell cycle at the G2/M checkpoint. VPRBP (Vpr (HIV-1) binding protein), also known as DCAF1 or RIP, is a 1,507 amino acid cytoplasmic protein that contains one LisH domain and functions as a Vrp binding protein. Expressed ubiquitously, VPRBP is thought to act as a receptor for the CUL-4-DDB1 complex and, in response to HIV infection, interacts with Vpr and may cause cell cycle arrest at the G2 phase. Multiple isoforms of VPRBP exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of VPRBP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1101-1400 mapping near the C-terminus of VPRBP of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1101-1400 mapping near the C-terminus of VPRBP of human origin |
| Entrez Gene | 9730 |
|---|
| Application Notes | recommended for detection of VPRBP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
