| Product Name | PHLDA3 Antibody (H-54) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 31-78 of PHLDA3 of human origin |
| Modification Notes | PHLDA3 (pleckstrin homology-like domain, family A, member 3), also known as TIH1, is a 127 amino acid protein that contains one PH domain and is expressed in a variety of tissues, with particularly low expression in spleen and liver tissue. Sharing nearly 100% sequence homology with its mouse counterpart, PHLDA3 functions as a tumor suppressor that inhibits Akt signaling and is required for p53-dependent apoptosis. The gene encoding PHLDA3 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PHLDA3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 31-78 of PHLDA3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 31-78 of PHLDA3 of human origin |
| Entrez Gene | 23612 |
|---|
| Application Notes | recommended for detection of PHLDA3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
