Application
Western blot analysis of QDPR expression in non-transfected: (A) and human QDPR transfected: (B) 293T whole cell lysates.Application
Western blot analysis of QDPR expression in non-transfected: (A) and mouse QDPR transfected: (B) 293T whole cell lysates.Application
Western blot analysis of QDPR expression in HL-60 whole cell lysate.| Product Name | QDPR Antibody (H-234) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 11-244 mapping at the C-terminus of QDPR of human origin |
| Modification Notes | QDPR (quinoid dihydropteridine reductase), also known as DHPR (dihydropteridine reductasae) or PKU2, is a member of the short-chain dehydrogenases/reductase (SDR) family of enzymes. Functioning as a homodimer, QDPR plays an important role in the recycling of tetrahydrobiopterin (BH4), an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine). More specifically, QDPR catalyzes the regeneration of BH4 from quinonoid dihydrobiopterin (qBH2), the product generated from the hydroxylation reactions. Mutations in the gene encoding QDPR can lead to phenylketonuria II (also called PK2 or dihydropteridine reductase deficiency), a disorder resulting from the depletion of dopamine, epinephrine and serotonin due to defective recycling of BH4. Symptoms of PK2 include hyperphenylalaninemia, axial hypotonia, truncal hypertonia, microcephaly and abnormal thermogenesis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of QDPR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 11-244 mapping at the C-terminus of QDPR of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 11-244 mapping at the C-terminus of QDPR of human origin |
| Entrez Gene | 5860 |
|---|
Application
Western blot analysis of QDPR expression in non-transfected: (A) and human QDPR transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of QDPR expression in non-transfected: (A) and mouse QDPR transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of QDPR expression in HL-60 whole cell lysate.| Application Notes | recommended for detection of QDPR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
