| Modification Notes |
SFMBT1 (scm-like with four MBT domains protein 1), also known as renal ubiquitous protein 1 (RU1), is a 866 amino acid protein with high sequence similarity to the Drosophila scm protein. Drosophila scm is a transcriptional repressor essential for Drosophila development. SFMBT1 is expressed in all cell lines and normal tissues, including the thymus, and localizes to the nucleus. SFMBT1 contains four MBT repeats and one SAM (sterile alpha motif) domain. The MBT motif has been identified as a key domain capable of methyl-lysine histone recognition. Considered a polycomb protein, SFMBT1 strongly associates with chromatin and may function as a transcriptional repressor. Two isoforms exist due to alternative splicing events. |