| Modification Notes |
CMTM6 (CKLF-like MARVEL transmembrane domain containing 6), also known as CKLFSF6 (chemokine-like factor superfamily member 6), is a 183 amino acid member of the chemokine-like factor family. Members of the chemokine-like factor family share similarity with the chemokine and the transmembrane 4 superfamilies. CMTM6 is a multi-pass membrane protein containing one MARVEL domain. MARVEL domain-containing proteins are usually associated with specialized membrane microdomains. Through these specialized membrane microdomains, MARVEL proteins can influence a variety of cellular processes (ie., vesicular transport carriers or tight junction regulation). CMTM6 is predominantly expressed in testis, placenta and leukocytes. Human CMTM6 shares 83% similarity with its mouse homolog. |