| Product Name | R-Spondin4 Antibody (P-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of R-Spondin4 of human origin |
| Modification Notes | Roof plate-specific Spondins (R-Spondins) are secreted proteins that possess a Furin-like cysteine-rich domain and are involved in regulating ∫-catenin function. R-Spondin4, also known as RSPO4, is a 234 amino acid secreted protein that, characteristic of R-Spondins, contains one Furin-like repeat and one TSP type-1 domain. R-Spondin4 interacts with heparin and is able to activate the ∫-catenin signaling cascade, possibly via control of the Wnt/∫-catenin signaling pathway. Defects in the gene encoding R-Spondin4 are the cause of anonychia, an autosomal recessive condition characterized by severe hypoplasia (underdevelopment) of fingernails and toenails. R-Spondin4 exists as multiple alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 20. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of R-Spondin4 of mouse, rat and human origin by WB, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of R-Spondin4 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of R-Spondin4 of human origin |
| Entrez Gene | 343637 |
|---|
| Application Notes | recommended for detection of R-Spondin4 of mouse, rat and human origin by WB, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
