| Product Name | SPRED2 Antibody (H-60) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 30-87 mapping near the N-terminus of SPRED2 of human origin |
| Modification Notes | SPRED2 (Sprouty-related, EVH1 domain-containing protein 2) is a 418 amino acid protein that localizes to the peripheral membrane and contains one WH1 domain, one sprouty domain and one KBD domain. Expressed in prostate, skin, liver, salivary gland and small intestine, SPRED2 exists as a homodimer or a heterodimer (with SPRED1) that functions as a tyrosine kinase substrate and acts to inhibit growth-factor-induced MAP kinase (ERK 2) cascade activation. Human SPRED2 is subject to phosphorylation on Tyr 228 or Tyr 231, an event that leads to the ubiquitination and subsequent degradation of SPRED2 by the proteasome. Abnormal expression of SPRED2 is associated with a variety of malignant tumors, suggesting a role for SPRED2 in carcinogenesis. Additionally, disruption of the gene encoding SPRED2 that leads to an activation of the ERK 2 pathway may cause dwarfism. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SPRED2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 30-87 mapping near the N-terminus of SPRED2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 30-87 mapping near the N-terminus of SPRED2 of human origin |
| Entrez Gene | 200734 |
|---|
| Application Notes | recommended for detection of SPRED2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
