| Product Name | RTEL1 Antibody (E-19) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of RTEL1 of human origin |
| Modification Notes | RTEL1 (regulator of telomere elongation helicase 1), also known as C20orf41, KIAA1088 or NHL, is a 1,400 amino acid nuclear protein that contains one helicase ATP-binding domain and belongs to the helicase family of DNA-binding proteins. In mice, RTEL1 is required for telemore elongation and is an important regulator of chromosome stability. Human RTEL1 is highly expressed in kidney and intestine and, existing as a functional ortholog of its mouse counterpart, is thought to act as an ATP-dependent helicase that may regulate chromosome function and genomic stability. The gene encoding RTEL1 maps to a gene-rich cluster on chromosome 20 that is thought to house a number of tumor-related genes, suggesting that RTEL1 may play a role in tumorigenesis. Multiple isoforms of RTEL1 exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of RTEL1 of human origin by WB, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of RTEL1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of RTEL1 of human origin |
| Entrez Gene | 51750 |
|---|
| Application Notes | recommended for detection of RTEL1 of human origin by WB, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
