| Modification Notes |
C21orf99 (ANKRD30BP2), also known as ankyrin repeat domain 30B pseudogene 2, CT85, CTSP1 or CTSP-1, is a 68 amino acid protein that, characteristic of CT (cancer/testis) antigens, displays a restricted expression pattern in normal tissues. Encoded by a gene that maps to human chromosome 21q11.2, C21orf99 is highly conserved and shares similarity to the 5′region of the breast differentiation antigen ANKRD30A gene. C21orf99 is predominantly expressed in testis and is also expressed in prostate, brain, placenta and trachea. C21orf99 is not expressed in lung, small intestine, breast, heart, uterus, bone marrow, fetal brain, colon, fetal liver, liver, thymus, salivary glands, spinal chord, kidney, spleen, muscle and adrenal gland. C21orf99 is suggested to produce humoral response in cancer patients due to its high expression in tumor cells. |