| Modification Notes |
The Microrchidia (Morc) family of proteins includes four predicted members in human (Morc1, Morc2, Morc3 and Morc4) and five in mice (Morc1, Morc2a, Morc2b, Morc3 and Morc4). MORC family CW-type zinc finger protein 3 (Morc3), also known as zinc finger CW-type coiled-coil domain protein 3 (ZCWCC3), is a 939 amino acid protein belonging to the MORC family. Ubiquitously expressed in human cell lines, Morc3 contains one CW-type zinc finger and is localized to the nuclear matrix. Morc3 has been shown to play a role in recruiting p53 and SP-100 to promyelocytic leukemia (PML)-nuclear bodies (NBs). Furthermore, Morc3 regulates p53 activation in a manner dependent on Morc3-ATPase activity. |