| Modification Notes |
Members of the WD repeat protein family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis and gene regulation. BRWD1 (bromodomain and WD repeat-containing protein 1), also known as N143 or WDR9, is a 2320 amino acid protein that is ubiquitously expressed. Localizing to both the cytoplasm and the nucleus, BRWD1 may be involved in chromatin remodeling and may act as a transcriptional activator. It is suggested that BRWD1 is required for normal spermiogenesis and the oocyte-embryo transition. BRWD1 contains two bromo domains and eight WD repeats. The gene that encodes BRWD1 is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates 3 transcript variants diverging at the 3' ends. |