Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human cancer tissue showing cytoplasmic staining.| Product Name | PRDM16 Antibody (N-16) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | a purified recombinant GST-fusion protein containing N-terminal amino acids 13-316 of PRDM16 of human origin |
| Modification Notes | The PR-domain containing proteins (PRDMs) have a common involvement in the modulation of gene activities. A PR-domain family member usually produces two products, called PR-plus and PR-minus, which differ by the presence or absence of the PR domain, respectively. The PR-plus product is underexpressed or disrupted in cancer cells, whereas the PR-minus product is present or overexpressed in cancer cells. This imbalance in the amount of the two products, which is a result of either genetic or epigenetic events, appears to be a determining factor of malignancy. PRDM16 (PR domain containing 16), also known as MEL1 or PFM13, is a 1,276 amino acid protein that contains one SET domain and ten C2H2-type zinc fingers. Localized to the nucleus, PRDM16 functions as a transcription factor and is thought to be involved in the pathogenesis of acute myeloid leukemia and myelodysplastic syndrome. Three isoforms of PRDM16 exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IFIHCELISA |
| recommended for detection of PRDM16 of human origin by IF, IHC(P) and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | a purified recombinant GST-fusion protein containing N-terminal amino acids 13-316 of PRDM16 of human origin |
|---|---|
| Tissue Specificity | a purified recombinant GST-fusion protein containing N-terminal amino acids 13-316 of PRDM16 of human origin |
| Entrez Gene | 63976 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human cancer tissue showing cytoplasmic staining.| Application Notes | recommended for detection of PRDM16 of human origin by IF, IHC(P) and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
