Application
Western blot analysis of KLHDC4 expression in non-transfected: (A) and human KLHDC4 transfected: (B) 293T whole cell lysates.| Product Name | KLHDC4 Antibody (T-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the C-terminus of KLHDC4 of human origin |
| Modification Notes | KLHDC4 (kelch domain-containing protein 4) is a 520 amino acid protein that contains six kelch repeats and exists as three alternatively spliced isoforms. The gene encoding KLHDC4 maps to human chromosome 16q24.2 and mouse chromosome 8 E1. Chromosome 16 encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, through the CREBBP gene which encodes a critical CREB binding protein. Signs of Rubinstein-Taybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of KLHDC4 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other KLHDC family members also reactive with additional species, including equine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the C-terminus of KLHDC4 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the C-terminus of KLHDC4 of human origin |
| Entrez Gene | 54758 |
|---|
Application
Western blot analysis of KLHDC4 expression in non-transfected: (A) and human KLHDC4 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of KLHDC4 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other KLHDC family members also reactive with additional species, including equine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
