Application
Western blot analysis of STYX expression in non-transfected 293T: (A), human STYX transfected 293T: (B) and WI 38 (C) whole cell lysates.Application
Western blot analysis of STYX expression in non-transfected 293T: (A), mouse STYX transfected 293T: (B) and WI 38 (C) whole cell lysates.Application
Western blot analysis of STYX expression in non-transfected 293T: (A), human STYX transfected 293T: (B) and WI 38 (C) whole cell lysates.| Product Name | STYX Antibody (H-90) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 134-223 mapping at the C-terminus of STYX of human origin |
| Modification Notes | STYX (serine/threonine/tyrosine-interacting protein), also known as protein tyrosine phosphatase-like protein, is a 223 amino acid protein that belongs to the protein-tyrosine phosphatase family and the non-receptor class subfamily. Although STYX contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase, the binding pocket on STYX is sufficiently preserved to bind phosphorylated substrates and possibly protect them from phosphatases. STYX interacts with CARHSP1/CRHSP-24 and may play a role in spermiogenesis. The gene that encodes STYX contains 44,834 bases and maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder å1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of STYX of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 134-223 mapping at the C-terminus of STYX of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 134-223 mapping at the C-terminus of STYX of human origin |
| Entrez Gene | 6815 |
|---|
Application
Western blot analysis of STYX expression in non-transfected 293T: (A), human STYX transfected 293T: (B) and WI 38 (C) whole cell lysates.
Application
Western blot analysis of STYX expression in non-transfected 293T: (A), mouse STYX transfected 293T: (B) and WI 38 (C) whole cell lysates.
Application
Western blot analysis of STYX expression in non-transfected 293T: (A), human STYX transfected 293T: (B) and WI 38 (C) whole cell lysates.| Application Notes | recommended for detection of STYX of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
