| Product Name | AAK1 Antibody (C-15) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the C-terminus of AAK1 of human origin |
| Modification Notes | Adaptor-related protein complex 2 (AP-2 complexes) operates during receptor-mediated endocytosis to initiate clathrin assembly, associates with membrane-bound receptors and mobilizes encodytic accessory factors. AAK1 (AP2 associated kinase 1), also known as adaptor-associated kinase 1, is a 961 amino acid protein belonging to the protein kinase superfamily and the serine/threonine protein kinase family. Encoded by a gene that maps to human chromosome 2p14, AAK1 participates in ATP and nucleotide binding, protein serine/threonine kinase functions and transferase activity. AAK1 phosphorylates a subunit of the AP-2 complex, which leads to binding of AP-2 to sorting signals in membrane-bound receptors, resulting in receptor endocytosis. AAK1 contains one protein kinase domain, with kinase activity stimulated by clathrin, and exists as two alternatively spliced isoforms. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| recommended for detection of AAK1 of mouse, rat and human origin by WB: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the C-terminus of AAK1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the C-terminus of AAK1 of human origin |
| Entrez Gene | 22848 |
|---|
| Application Notes | recommended for detection of AAK1 of mouse, rat and human origin by WB: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
