Application
Western blot analysis of SLC25A22 expression in non-transfected: (A) and mouse SLC25A22 transfected: (B) 293T whole cell lysates and mouse brain tissue extract (C).Application
Western blot analysis of SLC25A22 expression in Jurkat whole cell lysate.Application
Immuno-peroxidase staining of formalin fixed, paraffin-embedded human muscle tissue showing cytoplasmic staining.| Product Name | SLC25A22 Antibody (M-22) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against SLC25A22 of human origin |
| Modification Notes | SLC25A22 (solute carrier family 25 member 22), also known as GC1 (mitochondrial glutamate carrier 1), is a 323 amino acid multi-pass membrane protein that belongs to the the SLC25 family of mitochondrial carriers that are responsible for transporting metabolites across the inner mitochondrial membrane. Existing as one of only two known mitochondrial glutamate/H+ symporters, SLC25A22 is widely expressed and localizes to the mitochondrion inner membrane. SLC25A22 contains three Solcar repeats and plays an important role in the transport of glutamate across the inner mitochondrial membrane. Mutations in the gene encoding SLC25A22 are associated with myoclonic encephalopathy (EME). EME, also called neonatal epilepsy with suppression-burst pattern, is an autosomal recessive disorder characterized by early onset, massive myoclonus that is generally erratic and fragmentary, late tonic spasms and partial motor seizures. Patients with this disorder typically do not survive beyond 1-2 years after birth. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of SLC25A22 of mouse and human origin by WB, IP, IF, IHC(P) and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against SLC25A22 of human origin |
|---|---|
| Tissue Specificity | raised against SLC25A22 of human origin |
| Entrez Gene | 79751 |
|---|
Application
Western blot analysis of SLC25A22 expression in non-transfected: (A) and mouse SLC25A22 transfected: (B) 293T whole cell lysates and mouse brain tissue extract (C).
Application
Western blot analysis of SLC25A22 expression in Jurkat whole cell lysate.
Application
Immuno-peroxidase staining of formalin fixed, paraffin-embedded human muscle tissue showing cytoplasmic staining.| Application Notes | recommended for detection of SLC25A22 of mouse and human origin by WB, IP, IF, IHC(P) and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
