Application
Western blot analysis of ENDOD1 expression in non-transfected: (A) and human ENDOD1 transfected: (B) 293T whole cell lysates.| Product Name | ENDOD1 Antibody (Q-15) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of ENDOD1 of human origin |
| Modification Notes | ENDOD1 (endonuclease domain-containing 1 protein) is a 500 amino acid secreted protein that belongs to the DNA/RNA non-specific endonuclease family. ENDOD1 is thought to act as a DNase and an RNase. The gene that encodes ENDOD1 maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ENDOD1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of ENDOD1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of ENDOD1 of human origin |
| Entrez Gene | 23052 |
|---|
Application
Western blot analysis of ENDOD1 expression in non-transfected: (A) and human ENDOD1 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of ENDOD1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
