Application
Western blot analysis of GABAA Rγ2 expression in rat cerebellum (A), mouse cerebellum (B) and rat hippocampus (C) tissue extracts.| Product Name | GABAA Rγ2 Antibody (Q-18) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against GABAA Rγ2 of human origin |
| Modification Notes | GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system, GABA functions as the main inhibitory transmitter by increasing a Cl- (chloride) conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors, as well as a third class of receptors called GABAC. The © subunit of GABAA receptors are important for benzodiazepine binding and modulation of GABA-mediated Cl- current. GABAA R©2 is a 467 amino acid mulit-pass membrane protein localized to the postsynaptic cell membrane. Present as a pentamer with other GABAA receptor chains (å, ∫, ©, ∂ and r), the GABAA ligand-gated Cl- channels selectively complex with D5DR to enable mutual inhibitory functional interactions between the two receptor systems. Defects in the gene encoding GABAA R©2 have been found to be the cause of childhood absence epilepsy type 2, familial febrile convulsions type 8, generalized epilepsy with febrile seizures plus type 3 and severe myoclonic epilepsy in infancy. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| recommended for detection of GABAA Rγ2 of mouse, rat, human and canine origin by WB, IP and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against GABAA R&gamma 2 of human origin |
|---|---|
| Tissue Specificity | raised against GABAA Rγ2 of human origin |
| Entrez Gene | 2566 |
|---|
Application
Western blot analysis of GABAA Rγ2 expression in rat cerebellum (A), mouse cerebellum (B) and rat hippocampus (C) tissue extracts.| Application Notes | recommended for detection of GABAA Rγ2 of mouse, rat, human and canine origin by WB, IP and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
