| Product Name | DBR1 Antibody (G-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of DBR1 of human origin |
| Modification Notes | DBR1 (debranching enzyme homolog 1) is a 544 amino acid protein that localizes to the nucleus and belongs to the lariat debranching enzyme family. Functioning at an optimal pH of 7.0, DBR1 uses divalent metal cations to catalyze the cleavage of the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs, thereby converting the lariat structures to linear molecules that are subject to degradation. Via its catalytic activity, DBR1 facilitates ribonucleotide turnover and is thought to participate in retroviral (specifically HIV-1) replication. Human DBR1 shares 79% homology with its mouse counterpart, suggesting a conserved role between species. DBR1 is expressed as two alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 3. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of DBR1 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including canine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of DBR1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of DBR1 of human origin |
| Entrez Gene | 51163 |
|---|
| Application Notes | recommended for detection of DBR1 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including canine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
