Application
Western blot analysis of MISR II expression in ES-2 whole cell lysate.Application
Western blot analysis of MISR II expression in rat testis (A) and rat ovary (B) tissue extracts.| Product Name | MISR II Antibody (H-150) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-150 mapping within an N-terminal extracellular domain of MISR II of human origin |
| Modification Notes | MISR II (anti-Muellerian hormone type-2 receptor, MIS type II receptor) is a 573 amino acid protein encoded by the human gene AMHR2. MISR II belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily and contains one protein kinase domain. Upon ligand binding, MISR II forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. These type II receptors phospho-rylate and activate type I receptors which autophosphorylate, then bind and activate Smad transcriptional regulators. MISR II also acts as a receptor for anti-Muellerian hormone. Defects in AMHR2 are the cause of persistent Muellerian duct syndrome type 2 (PMDS-2). PMDS-2 is a form of male pseu-dohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MISR II of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-150 mapping within an N-terminal extracellular domain of MISR II of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-150 mapping within an N-terminal extracellular domain of MISR II of human origin |
| Entrez Gene | 269 |
|---|
Application
Western blot analysis of MISR II expression in ES-2 whole cell lysate.
Application
Western blot analysis of MISR II expression in rat testis (A) and rat ovary (B) tissue extracts.| Application Notes | recommended for detection of MISR II of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
