| Product Name | PDZ-RhoGEF Antibody (R-295) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1228-1522 mapping at the C-terminus of PDZ-RhoGEF of rat origin |
| Modification Notes | The multidomain (RGS)-containing RhoGEFs represent a family of guanine nucleotide exchange factors that stabilize the nucelotide-free state of small GTPases through their DH/PH domains, leading to the exchange of GDP to GTP. Uniquely, PDZ-RhoGEF, also known as Rho guanine nucleotide exchange factor 11 and ARHGEF11, binds tightly to both nucleotide-free and activated Rho A, therefore playing a role as a primary regulator of Rho A. Mutations within the carboxylate-binding loop of PDZ-RhoGEF result in changes in cell morphology and actin organization which is likely due to its interaction with MAP-1A (MAP1 light chain LC2). PDZ-RhoGEF also plays a role in B plexin-mediated activation of Rho/Rho kinase signaling, which is implicated in the regulation of axon guidance and cell migration. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PDZ-RhoGEF of mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1228-1522 mapping at the C-terminus of PDZ-RhoGEF of rat origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1228-1522 mapping at the C-terminus of PDZ-RhoGEF of rat origin |
| Entrez Gene | 213498 |
|---|
| Application Notes | recommended for detection of PDZ-RhoGEF of mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
