| Modification Notes |
The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. KIFC3 (kinesin family member C3) is an 833 amino acid minus end-directed and microtubule-dependent motor protein that contains one kinesin-motor domain and belongs to the kinesin superfamily. A cytoplasmic and peripheral membrane protein, KIFC3 is found in the zona adherens of confluent epithelial cells and in renal distal tubules and the loops of Henle. Encoded by a gene that maps to human chromosome 16q13, KIFC3 plays a role in maintaining the integrity of the zona adherens and apically targeted transport. |