| Product Name | Prestin Antibody (H-294) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 529-744 mapping at the C-terminus of Prestin of human origin |
| Modification Notes | The most impressive property of outer hair cells (OHCs) is their ability to change their length at high acoustic frequencies, thus providing the exquisite sensitivity and frequency-resolving capacity of the mammalian hearing organ. Prestin, a transmembrane protein found in the outer hair cells of the cochlea, is related to a sulfate/anion transport protein. In contrast to enzymatic-activity-based motors, Prestin is a direct voltage-to-force converter, which uses cytoplasmic anions as extrinsic voltage sensors and can operate at microsecond rates. Intracellular anions such as chloride or bicarbonate are essential for Prestin to function as the OHC motor molecule. As Prestin mediates changes in outer hair cell length in response to membrane potential variations, it may be responsible for sound amplification in the mammalian hearing organ. Additionally, the voltage sensitivity of Prestin is markedly temperature dependent. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Prestin isoforms 1-3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 529-744 mapping at the C-terminus of Prestin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 529-744 mapping at the C-terminus of Prestin of human origin |
| Entrez Gene | 375611 |
|---|
| Application Notes | recommended for detection of Prestin isoforms 1-3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
