| Product Name | ABCG4 Antibody (H-50) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 321-370 mapping within an N-terminal cytoplasmic domain of ABCG4 of human origin |
| Modification Notes | ATP-binding cassette (ABC) transporters are an evolutionarily conserved family of proteins that catalyze the transport of molecules across extra- and intracellular membranes through the energy of ATP hydrolysis. The ABC gene family comprises seven subfamilies, ABC1, MDR/TAP, MRP, ALD, OABP, GCN20 and White. ABC proteins are either full molecules, with two nucleotide-binding folds (NBFs) and two sets of transmembrane domains (TMs), or half molecules, with one NBF and one set of TM domains. ABCG4, as well as all other half transporters, forms either a hetero- or homodimer in order to mediate transport function. A 646 amino acid protein, ABCG4 is important in macrophage lipid homeostasis, with the highest expression detected in brain, thymus, spleen and heart. The gene encoding for the ABCG4 protein maps to chromosome 11q23.3, a locus which includes several other genes involved in cholesterol and lipid metabolism. This locus also includes the locus for primary hypoalphalipoproteinemia. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ABCG4 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 321-370 mapping within an N-terminal cytoplasmic domain of ABCG4 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 321-370 mapping within an N-terminal cytoplasmic domain of ABCG4 of human origin |
| Entrez Gene | 64137 |
|---|
| Application Notes | recommended for detection of ABCG4 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
