| Product Name | OSTα Antibody (N-15) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the N-terminus of OSTα of human origin |
| Modification Notes | The heteromeric transporter OSTå/OST∫ facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OSTå/OST∫ expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OSTå (organic solute transporter subunit alpha) is a 340 amino acid multi-pass membrane protein that requires interaction with OST∫ in order to reach the plasma membrane. In OSTå null mice, transileal transport of taurocholate was reduced by more than 80% and bile acid pool size was reduced by more than 65% when compared with wildtype mice, suggesting that OSTå is critical for intestinal bile acid transport. Though widely expressed, OSTå is present at highest levels in ileum. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of OSTα of mouse and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the N-terminus of OST&alpha of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the N-terminus of OSTα of human origin |
| Entrez Gene | 200931 |
|---|
| Application Notes | recommended for detection of OSTα of mouse and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
