Application
Western blot analysis of BACE expression in non-transfected: (A) and human BACE transfected: (B) 293T whole cell lysates.Application
Western blot analysis of human recombinant BACE fusion protein.| Product Name | BACE Antibody (M-83) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 419-501 of BACE of mouse origin |
| Modification Notes | Autosomal dominant Alzheimer’s disease is caused by mutations in the gene encoding the ß-amyloid protein precursor (APP). Amyloid ß-peptide (Aß), the major feature of amyloid plaques in Alzheimer’s patients, is the product of APP cleavage by ß- and g-secretases. BACE is the transmembrane protease which cleaves Aß from APP. BACE and the related protein Asp1 are both widely expressed in human tissue with the highest levels in the pancreas. BACE is localized within Golgi and endosomes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of BACE of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 419-501 of BACE of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 419-501 of BACE of mouse origin |
| Entrez Gene | 23621 |
|---|
Application
Western blot analysis of BACE expression in non-transfected: (A) and human BACE transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of human recombinant BACE fusion protein.| Application Notes | recommended for detection of BACE of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
