| Product Name | OPN1SW Antibody (H-40) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 257-296 mapping near the C-terminus of OPN1SW of human origin |
| Modification Notes | G protein-coupled receptors (GPCRs), which are characterized by containing seven transmembrane å helices, elicit G protein-mediated signaling cascades in response to a variety of stimuli. The opsin subfamily, which represents approximately 90 percent of all GPCRs, is comprised of photoreceptors that are activated by light. It includes the red-, green- and blue-sensitive opsins and rhodopsin. The opsin subfamily consists of an apoprotein covalently linked to 11-cis-retinal, which undergoes isomerization upon the absorption of photons. This isomerization leads to a conformational change of the protein, which results in the activation of hundreds of G proteins. Color is perceived in humans by three pigments, which localize to retinal cone photoreceptor cells. They are the blue-, green- and red-sensitive opsins, which are encoded by OPN1SW, OPN1MW and OPN1LW, respectively. Mutations in the OPN1MW and OPN1LW encoded opsins lead to the X-linked disorders protanopia and deuteranopia, respectively. Mutations in the OPN1SW encoded opsin leads to tritanopia, an autosomal dominant disorder, which is characterized by decreased sensitivity to blue light. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of OPN1SW of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 257-296 mapping near the C-terminus of OPN1SW of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 257-296 mapping near the C-terminus of OPN1SW of human origin |
| Entrez Gene | 611 |
|---|
| Application Notes | recommended for detection of OPN1SW of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
